Pubblicazioni
scientifiche

I nostri ricercatori contribuiscono al progresso della conoscenza scientifica attraverso pubblicazioni realizzate insieme ai centri e alle università con cui collaboriamo in tutto il mondo.

Allegretti M. Ruffini P. A. D’Anniballe G. Brandolini L. Bertini R. Aramini A. Antonosante A. Ferrari M. P. Mantelli F. Beccari A. Noncompetitive allosteric inhibitors of the inflammatory chemokine... CXCR1/2 inhibition enhances pancreatic islet... Safety and pharmacokinetics of escalating... Tumor-Produced Interleukin-8 Attracts... Targeting CXCR1 on breast cancer stem... Targeting the minor pocket of C5aR... CXCR1 and CXCR2 Chemokine Receptor... CXCR1/2 pathways in paclitaxel-induced... Phase II Randomized, Double-Masked... CXCR1/2 Inhibition Blocks and... Role of the chemokine receptor... Receptor binding mode and... Therapeutic inhibition of CXCR2 by... Phase Ib Pilot Study to Evaluate... Chemokine Signaling in... Blockade of the chemokine receptor... Allosteric inhibitors of chemoattractant... Topical Recombinant Human Nerve... CXCR1/2 Antagonism Is Protective... Autocrine CXCL8-dependent... Phase I Trial of Recombinant... Intravital Microscopic Evaluation of... A window-of-opportunity trial of the... The Novel C5aR Antagonist DF3016A... IL-6 and CXCL8 Mediate... Multiple Anti-Tumor Effects of Reparixin... Ladarixin, a Dual CXCR1/2 Inhibitor... CXCR1 and CXCR2 Inhibition by Ladarixin... Targeting CXCR1/2 does not improve insulin... CXCR2 Is Critical for Bacterial Control and... Emerging Role of C5 Complement Pathway in... Inhibition of osteoclast activity by complement... A randomized, placebo-controlled phase 2 study of paclitaxel... Islet allotransplantation in type 1 diabetes: Phase 2 pilot study with... CXCR2 inhibition improves islet transplantation Effect of topical recombinant human nerve growth factor... IL6 and CXCL8 mediate redundant, targetable tumor-host interactions... Phase I, randomized, double-masked, vehicle-controlled study to evaluate safety... Targeting CXCR1/2 in the first multicenter, double-blinded, randomized trial in... Tooltip

Pharmaceuticals giugno 2021

Unexpected Salt/Cocrystal Polymorphism of the Ketoprofen-Lysine System: Discovery of a New Ketoprofen-l-Lysine Salt Polymorph with Different Physicochemical and Pharmacokinetic Properties

Andrea Aramini, Gianluca Bianchini, Samuele Lillini, Simone Bordignon, Mara Tomassetti, Rubina Novelli, Simone Mattioli, Larisa Lvova, Roberto Paolesse, Michele Remo Chierotti, Marcello Allegretti

American Journal of Transplantation maggio 2021

Targeting CXCR1/2 in the first multicenter, double-blinded, randomized trial in autologous islet transplant recipients

Piotr Witkowski, Martin Wijkstrom, Piotr J. Bachul, Katherine A. Morgan, Marlon Levy, Nicholas Onaca, Sushela S. Chaidarun, Timothy Gardner, A.M. James Shapiro, Andrew Posselt, Syed A. Ahmad, Luisa Daffonchio, Pier A. Ruffini, Melena D. Bellin

Int. J. Mol. Sci. maggio 2021

Altered Local Interactions and Long-Range Communications in UK Variant (B. 1.1. 7) Spike Glycoprotein

Stefano Borocci, Carmen Cerchia, Alessandro Grottesi, Nico Sanna, Ingrid Guarnetti Prandi, Nabil Abid, Andrea R. Beccari, Giovanni Chillemi and Carmine Talarico

Science maggio 2021

X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease

Sebastian Günther et al.

Biomedicine and Pharmacotherapy aprile 2021

A new synthetic dual agonist of GPR120/GPR40 induces GLP-1 secretion and improves glucose homeostasis in mice

Gianluca Bianchini, Cecilia Nigro, Anna Sirico, Rubina Novelli, Immacolata Prevenzano, Claudia Miele, Francesco Beguino, Andrea Aramini

Biomedicines aprile 2021

Emerging Role of C5 Complement Pathway in Peripheral Neuropathies: Current Treatments and Future Perspectives

Cristina Giorgio, Mara Zippoli, Pasquale Cocchiaro, Vanessa Castelli, Giustino Varrassi, Andrea Aramini, Marcello Allegretti, Laura Brandolini and Maria Candida Cesta

ACS Pharmacol. Transl. Sci. marzo 2021

A Blueprint for High Affinity SARS-CoV-2 Mpro Inhibitors from Activity-Based Compound Library Screening Guided by Analysis of Protein Dynamics

Jonas GossenJonas Gossen, Simone Albani, Anton Hanke, Benjamin P. Joseph, Cathrine Bergh, Maria Kuzikov, Elisa Costanzi, Candida Manelfi, Paola Storici, Philip Gribbon, Andrea R. Beccari, Carmine Talarico, Francesca Spyrakis, Erik Lindahl, Andrea Zaliani, Paolo Carloni, Rebecca C. Wade, Francesco Musiani, Daria B. Kokh, and Giulia Rossetti

ACS Pharmacol. Transl. Sci. marzo 2021

Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen

Maria Kuzikov, Elisa Costanzi, Jeanette Reinshagen, Francesca Esposito, Laura Vangeel, Markus Wolf, Bernhard Ellinger, Carsten Claussen, Gerd Geisslinger, Angela Corona, Daniela Iaconis, Carmine Talarico, Candida Manelfi, Rolando Cannalire, Giulia Rossetti, Jonas Gossen, Simone Albani, Francesco Musiani, Katja Herzog, Yang Ye, Barbara Giabbai, Nicola Demitri, Dirk JochmansDirk Jochmans, Steven De Jonghe, Jasper Rymenants, Vincenzo Summa, Enzo Tramontano, Andrea R. Beccari, Pieter Leyssen, Paola Storici, Johan Neyts, Philip Gribbon, and Andrea Zaliani

Molecules febbraio 2021

Combining Different Docking Engines and Consensus Strategies to Design and Validate Optimized Virtual Screening Protocols for the SARS-CoV-2 3CL Protease

Candida Manelfi, Jonas Gossen, Silvia Gervasoni, Carmine Talarico, Simone Albani, Benjamin Joseph Philipp, Francesco Musiani, Giulio Vistoli, Giulia Rossetti, Andrea Rosario Beccari, Alessandro Pedretti

J. Med. Chem. novembre 2020

Targeting SARS-CoV-2 Proteases and Polymerase for COVID-19 Treatment: State of the Art and Future Opportunities

Cannalire R et al.,

Dompé farmaceutici S.p.A. Socio Unico / Capitale sociale € 50.000.000,00
REA MI 289519 - Registro Imprese di Milano / Codice Fiscale e Partita IVA (VAT) IT00791570153

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