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1890

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1902 - 1908

Team Members

Take a closer look at the team by clicking the single profiles.

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Clinical Pipeline

With our research and development pipeline, we target some of the highest-needing therapeutic areas.

Platform - Asset	Indication	Phase 1 Phase 2 Phase 3 Post-Market
Ophtha - NGF	Front-of-the-eye: Neurotrophic Keratitis
Ophtha - NGF	Front-of-the-eye: Sjogren-related Dry Eye
Ophtha - NGF Intravitreal	Back-of-the-eye
NETosis - Reparixin	Community Acquired Pneumonia (CAP)
NETosis - Reparixin	Acute Respiratory Distress Syndrome (ARDS)
NETosis - Ladarixin	Type 1 Diabetes – Early Onset
NETosis - Ladarixin	Type 1 Diabetes – Insulin resistant
Primary Care - KLS-Gaba	Low-back pain

Ophtha - NGF

Indication: Front-of-the-eye: Neurotrophic Keratitis

Project Status:

Phase 1:
Phase 2:
Phase 3:
Post-Market:

Ophtha - NGF

Indication: Front-of-the-eye: Sjogren-related Dry Eye

Project Status:

Phase 1:
Phase 2:
Phase 3:
Post-Market:

Ophtha - NGF Intravitreal

Indication: Back-of-the-eye

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Phase 1:
Phase 2:
Phase 3:
Post-Market:

NETosis - Reparixin

Indication: Community Acquired Pneumonia (CAP)

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Phase 1:
Phase 2:
Phase 3:
Post-Market:

NETosis - Reparixin

Indication: Acute Respiratory Distress Syndrome (ARDS)

Project Status:

Phase 1:
Phase 2:
Phase 3:
Post-Market:

NETosis - Ladarixin

Indication: Type 1 Diabetes – Early Onset

Project Status:

Phase 1:
Phase 2:
Phase 3:
Post-Market:

NETosis - Ladarixin

Indication: Type 1 Diabetes – Insulin resistant

Project Status:

Phase 1:
Phase 2:
Phase 3:
Post-Market:

Primary Care - KLS-Gaba

Indication: Low-back pain

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Phase 1:
Phase 2:
Phase 3:
Post-Market:

Publications

Our researchers contribute to the advancement of scientific knowledge through publications produced together with the centers and universities with which we collaborate all over the world.

Publications (YTD)

Mentions & Citation (YTD)

Cough & Cold

Diabetology

Nutrition

Oncology

Ophthalmology

Pain & Antiflammation

Preclinical Programs

Sars-Cov-2

Physiochemical Characterization of Lipidic Nanoformulations Encapsulating the Antifungal Drug Natamycin

20/04/2024

Authors: Luigi Talarico, Ilaria Clemente, Alessandro Gennari, Giulia Gabbricci, Simone Pepi, Gemma Leone, Claudia Bonechi, Claudio Rossi, Simone Luca Mattioli, Nicola Detta and Agnese Magnani

Published in:

Nanomaterials

Preclinical Programs

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Enabling performance portability on the LiGen drug discovery pipeline

16/04/2024

Authors: Luigi Crisci a, Lorenzo Carpentieri, Biagio Cosenza, Gianmarco Accordi, Davide Gadioli, Emanuele Vitali, Gianluca Palermo, Andrea Rosario Beccari

Published in:

Future Generation Computer Systems

Preclinical Programs

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Unlocking performance portability on LUMI-G supercomputer: A virtual screening case study

08/04/2024

Authors: Gianmarco Accordi, Davide Gadioli, Gianluca Palermo, Luigi Crisci, Lorenzo Carpentieri, Biagio Cosenza, Andrea R. Beccari

Published in:

ACM Digital Library

Preclinical Programs

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New disposable esthesiometer (KeraSenseR) to improve diagnosis and management of neurotrophic keratitis

21/03/2024

Authors: Francesca Giovannetti , Marta Sacchetti , Marco Marenco , Ludovico Alisi , Giacomo Visioli , Alice Bruscolini , Alessandro Lambiase

Published in:

The Ocular Surface

Preclinical Programs

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Drug repurposing screen to identify inhibitors of the RNA polymerase (nsp12) and helicase (nsp13) from SARS-CoV-2 replication and transcription complex

16/03/2024

Authors: Maria Kuzikov, Jeanette Reinshagen, Krzysztof Wycisk, Angela Corona, Francesca Esposito, Paolo Malune, Candida Manelfi, Daniela Iaconis, Andrea Beccari, Enzo Tramontano, Marcin Nowotny, Björn Windshügel, Philip Gribbon, Andrea Zaliani

Published in:

Virus Research

SARS-CoV-2

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ProNGF processing in adult rat tissues and bioactivity of NGF prodomain peptides

01/03/2024

Authors: Marie Anne Makoudjou, Elena Fico, Pamela Rosso, Viviana Triaca, Lucio De Simone, Daniela Rossetti, Franca Cattani, Marcello Allegretti and Paola Tirassa

Published in:

FEBS Open Bio

Preclinical Programs

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"DompeKeys": a set of novel substructure-based descriptros for efficient chemical space mapping, development and structural interpretation of machine learning models, and indexing of large databases

23/02/2024

Authors: Candida Manelfi, Valerio Tazzari, Filippo Lunghini, Carmen Cerchia, Anna Fava, Alessandro Pedretti, Pieter F. W. Stouten, Giulio Vistoli & Andrea Rosario Beccari

Published in:

Journal of Cheminformatics

Preclinical Programs

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Role of airway epithelium in viral respiratory infections: Can carbocysteine prevent or mitigate them?

14/02/2024

Authors: Elisabetta Pace, Serena Di Vincenzo, Maria Ferraro, Luigi Lanata, Francesco Scaglione

Published in:

Immunology

Pain & Antiflammation

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Phase IV multicenter, prospective, open-label clinical trial of cenegermin (rhNGF) for stage 1 neurotrophic keratopathy (DEFENDO)

13/02/2024

Authors: Pedram Hamrah, Mina Massaro-Giordano, David Schanzlin, Edward Holland, Gregg Berdy, Giovanni Goisis, Georgea Pasedis & Flavio Mantelli

Published in:

Ophthalmology and Therapy

Preclinical Programs

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Out of kernel tuning and optimizations for portable large‐scale docking experiments on GPUs

02/02/2024

Authors: G Accordi, D Gadioli, E Vitali, L Crisci, B Cosenza, A Beccari, G Palermo

Published in:

The Journal of Supercomputing

Preclinical Programs

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Who can make a request?

Only the treating physician on behalf of the patient can request a Dompé product, provided it is allowed by the applicable local laws.

How can I make a request?

Only the treating physician can request a Dompé product, provided it is allowed by applicable local laws.

The physician who wants to send the request, must fill this form.